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Wednesday, 17 January 2018

GARY SPEED, WELSH FOOTBALLER



                                                              Gary Speed, Wiki



Gary Andrew SpeedMBE (8 September 1969 – 27 November 2011) was a Welsh professional footballer and manager.
As a player, he is best known for his spell between 1988 and 1996 at Leeds United where he won the English Football League First Division Championship in 1992, and also for his spell between 1998 and 2004 at Newcastle United as well as three and a half years at Bolton Wanderers during their days under Sam Allardyce's management. He captained the Wales national football team until retiring from international football in 2004. He remains the most capped outfield player for Wales and the second overall, having appeared 85 times at senior level between 1990 and 2004, playing mainly as a left-side attacking midfielder. He started off his career in 1988 and retired in 2010. Speed was appointed manager of Sheffield United in 2010, but left the club after a few months in December 2010 to manage the Wales national team, remaining in this role until his death 11 months later. Speed played professionally for Leeds UnitedEvertonNewcastle UnitedBolton Wanderers and Sheffield United. Rarely troubled by injury or suspension, he held the record for the most appearances in the Premier League at 535, until it was surpassed by David James.


                                                                            

Sunday, 14 January 2018

THE SIDE AND WITHDRAWAL EFFECTS OF KLONOPIN (CLONAZEPAM)


I have been prescribed with klonopin for a total of about 3 years in the past, for anxiety. I am wondering whether this was responsible for some of my physical side effects (e.g. excess uric acid) which later combined with those from Epilim Crono.



Common[edit]

Less common[edit]

  • Confusion[5]
  • Irritability and aggression[34]
  • Psychomotor agitation[35]
  • Lack of motivation[36]
  • Loss of libido
  • Impaired motor function[vague]
    • Impaired coordination
    • Impaired balance
    • Dizziness
  • Cognitive impairments[vague][37]
  • Some users report hangover-like symptoms of drowsiness, headaches, sluggishness, and irritability upon waking up if the medication was taken before sleep. This is likely the result of the medication's long half-life, which continues to affect the user after waking up.[41]
[42][43] While benzodiazepines induce sleep, they tend to reduce the quality of sleep by suppressing or disrupting REM sleep.[44] After regular use, rebound insomnia may occur when discontinuing clonazepam.[45]

Occasional[edit]

Rare[edit]

  • Suicide through disinhibition[6]
  • Psychosis[53]
  • Incontinence[54][55][56]
  • Liver damage[57]
  • Paradoxical behavioural disinhibition[5][58] (most frequently in children, the elderly, and in persons with developmental disabilities)
    • Rage
    • Excitement
    • Impulsivity

Drowsiness[edit]

Clonazepam, like other benzodiazepines, may impair a person's ability to drive or operate machinery. The central nervous system depressing effects of the drug can be intensified by alcohol consumption, and therefore alcohol should be avoided while taking this medication. Benzodiazepines have been shown to cause dependence. Patients dependent on clonazepam should be slowly titrated off under the supervision of a qualified healthcare professional to reduce the intensity of withdrawal or rebound symptoms.

Withdrawal-related[edit]

  • Anxiety, irritability, insomnia, tremors
  • Potential to exacerbate existing panic disorder upon discontinuation
  • Seizures[60] similar to delirium tremens (with long-term use of excessive doses)
Benzodiazepines such as clonazepam can be very effective in controlling status epilepticus, but, when used for longer periods of time, some potentially serious side-effects may develop, such as interference with cognitive functions and behavior.[61] Many individuals treated on a long-term basis develop a dependence. Physiological dependence was demonstrated by flumazenil-precipitated withdrawal.[62] Use of alcohol or other CNS depressants while taking clonazepam greatly intensifies the effects (and side-effects) of the drug.
A recurrence of symptoms of the underlying disease should be separated from withdrawal symptoms.[63]

Tolerance and withdrawal[edit]

Like all benzodiazepines, clonazepam is a GABA-positive allosteric modulator.[64][65] One-third of individuals treated with benzodiazepines for longer than four weeks develop a dependence on the drug and experience a withdrawal syndrome upon dose reduction. High dosage and long-term use increase the risk and severity of dependence and withdrawal symptoms. Withdrawal seizures and psychosis can occur in severe cases of withdrawal, and anxiety and insomnia can occur in less severe cases of withdrawal. A gradual reduction in dosage reduces the severity of the benzodiazepine withdrawal syndrome. Due to the risks of tolerance and withdrawal seizures, clonazepam is generally not recommended for the long-term management of epilepsies. Increasing the dose can overcome the effects of tolerance, but tolerance to the higher dose may occur and adverse effects may intensify. The mechanism of tolerance includes receptor desensitization, down regulation, receptor decoupling, and alterations in subunit composition and in gene transcription coding.[5]
Tolerance to the anticonvulsant effects of clonazepam occurs in both animals and humans. In humans, tolerance to the anticonvulsant effects of clonazepam occurs frequently.[66][67] Chronic use of benzodiazepines can lead to the development of tolerance with a decrease of benzodiazepine binding sites. The degree of tolerance is more pronounced with clonazepam than with chlordiazepoxide.[68] In general, short-term therapy is more effective than long-term therapy with clonazepam for the treatment of epilepsy.[69] Many studies have found that tolerance develops to the anticonvulsant properties of clonazepam with chronic use, which limits its long-term effectiveness as an anticonvulsant.[70]
Abrupt or over-rapid withdrawal from clonazepam may result in the development of the benzodiazepine withdrawal syndrome, causing psychosis characterised by dysphoric manifestations, irritability, aggressiveness, anxiety, and hallucinations.[71][72][73] Sudden withdrawal may also induce the potentially life-threatening condition, status epilepticus. Anti-epileptic drugs, benzodiazepines such as clonazepam in particular, should be reduced in dose slowly and gradually when discontinuing the drug to mitigate withdrawal effects.[51] Carbamazepine has been tested in the treatment of clonazepam withdrawal but was found to be ineffective in preventing clonazepam withdrawal-induced status epilepticus from occurring.[74]

Friday, 12 January 2018

A CONVERSATION WITH ALEC GRANT, RETIRED READER OF NARRATIVE MENTAL HEALTH

Alec Grant shared John Read's post.
13 hrs
John Read
21 hrs
Lucy Johnstone opens launch of BPS alternatives to diagnosis conference in London
Comments
ALEC GRANT left the NHS in 1997, He is a retired Reader in Narrative Mental Health from the University of Brighton

Thomas Leonard the essenttial issue is as to whether Lucy still advocates the prescription of toxic psych meds during clinical treatment, as she clarified to me several months ago. Many supposed mental health conditions can be explained by previous trauma, but during diagnosis it is essential to consider condition or states of being on the spectrum, since they may not be completely explainable by previous trauma. Without this safeguard, I find Lucy's approach, as previously described to myself and James Carter in Edinburgh to be too simplistic
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Reply9h
Alec Grant Not simplistic at all m, Thomas. And not just Lucy's approach. Suggest you read the whole document in long and short form.
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Reply2h
Thomas Leonard I'm basing this on the information I previously received Alec. If the possibility of a condition on the spectrum is not considered then any trauma-based approach will be simplistic, Lucy advised me in Edinburgh that she has no knowledge of conditions on the spectrum. If she has improved her approach since, and stopped proscribing toxic psych meds, then all good to her,
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Reply1h
Alec Grant I don't think she's able to prescribe drugs in her professional role, Thomas. I also know that she's very aware of the dangers of drug use, in line with Joanna Moncrieff, David Healy and Peter Breggin.
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Reply58m
Thomas Leonard When I last corresponded with Lucy she indicated, albeit with some persuasion, that she'd sometimes felt compelled to prescribe psych meds in a clinical setting!
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Reply55m
Thomas Leonard As does David Healy ad nauseaum
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Reply54m
Thomas Leonard along with his ECT.
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Reply53m
Alec Grant As far as I'm aware, clinical psychologists have no prescribing powers?? She may have advocated this action though.
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Reply52m
Thomas Leonard Maybe you should ask Lucy! And Mr, Healey.
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Reply52m
Alec Grant My experience of Lucy and David are different from yours, Thomas. I'm not disagreeing with you but, respectfully, I'm surprised at what you say.
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Reply47m
Alec Grant Thanks for this Thomas. It's personally helpful. I wasn't aware of David Healy 's stance on ECT. I'm saddened by That, given what we know about this barbaric practice.
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Reply17m
Thomas Leonard Correction: According to the CATIE study around 70% of patients taking toxic psych meds stop their treatment during first fifteen months for some reason or other which includes debilitating side effects.
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Reply17m
Thomas Leonard Thank you, Alec. Beware all those who campaign since their motives may be quite different. I sometimes even wonder whether some campaigners are simply trying to help the Tories reduce the amount they spend on the mental health budget!
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Reply13m
Alec Grant I get surprised almost on a daily basis. Ginger Breggin, Peter Breggin 's wife, displays by her tweets that she is a David Trump supporter!
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Reply12m
Thomas Leonard quite apart from the Scientology rumours!!
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Reply11m
Alec Grant Thanks Thomas. Learned some things this morning!
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Reply11m
Alec Grant Ah now, the scientology stuff is nonsense Thomas. Used by the vile ortho camp to discredit high profile people in the crit MH communities.
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Reply9m
Thomas Leonard Let's keep talking, Alec.Here are a large number of other home truths, One of my mental deficiencies is that I'm entirely honest. And I'm sure that the Breggins are not Scientologists!http://www.thomashoskynsleonard.co.uk/psychiatric_home.htm
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ReplyRemove Preview8m
Alec Grant Thanks for this Thomas! I will read it with great interest later. Good to be connected with you!
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